Wound healing property of arosep (antidesma ghaesembilla, euphorbiaceae) leaves prepared as poultice in albino rats /

Wound healing property of arosep (antidesma ghaesembilla, euphorbiaceae) leaves prepared as poultice in albino rats / Elijah Joseph Dilan, Joyce Bitanga, Anna Dess Nuesca - - City of San Fernando, La Union : Lorma Colleges, 2020.

xvii, 97 leaves : color illustrations ; 29 cm.
Pharmacy (Thesis) -- Lorma Colleges, City of San Fernando, La Union, 2020.

Includes bibliographical references. Delayed healing of wounds increases chance of microbial infection. It can be improved through drugs that are administered locally or systematically but can also lead to misuse or overuse (WebMD, 2005). Wound is a break in any bodily tissue due to violence through any external factors (Billroth, theodor, 2019).
This study aimed to determine if Arosip (antidesma ghaesembilla) leaves prepared as poultice has a wound property in albino rats. To achieve the objectives of the study, the following procedures were perforemd: collection and cleaning of Arosep leaves, extraction, phytochemical screening, prepart=ation into poultice, patch and scratch test and furthermore testing of Arosep wound healing property where histopathological examination was performed.
Based on the result of Patch and Scratch Test, Arosep poultice is safe for topical application which resluted to zero (0) primary irritation index. In terms of the wound healing response of the Arosep poultice, complete re-epithelialization occured faster on the wound with Arosep poultice which started from the third (3rd) day and completed on the fifth (5th) day as compared to the untreated which started re-epithelialization on the fifth (5th) day and completed on the eight (8th) day. Based on the result of phytochemical analysis, Arosep leaves have been found to contain tannins and flavonoids which may be responsible for its wound healing property. Tannins chelate the free radicals and reactive species of oxygen, promote contraction of the wound and increase formation of capillary vessels and fibroblast (Kun, Diao, Zhang, Wang, & Zhen, 2011). Flavonoids help in the healing of wounds as it plays role as antioxidant and anti-inflammatory by controlling the release of eicosanoids, prostaglandins, leukotrienes and reactive oxygen species 9shahzad, et al., 2018).
In terms of its physicochemical characteristics, the prepared Arosep poultice has an acidic PH, and emerald green in color and changes into seaweed green upon storage. Based on the results, it is found that Arosep poultice gives a significant use as a wound healing agent which will help the people in Brgy. Arosip, Bacnotan, La Union.

Subjects--Topical Terms: --Wounds -- Healing.

Dewey Class. No.: PHA-TH 00043 D57 2020