Antiurolithiatic activity of katurai (sesbania granditflora fabaceae) extract in albino rats nad conformance of the formulated capsule to USP standards / Violy A. Baguan, Sarah Mae O. Delmendo, Nidie Marienne D. Halog, Emmanuel V. Mangaser; faculty researcher, Marianne A. Menecio

By: Contributor(s): Publication details: 2018. : Description: xix, 117 leaves: colored illustrations; 29 centimetersSubject(s): DDC classification:
  • PHA-TH 00026 B14 2018
Contents:
Kidney stone disease remains a significant health problem in the adult population, with serious medical consequences, throughout a patient's lifetime. Thus, the aim of this study is to raise awareness regarding the medicinal use of plants other than edibility. It also aimed to determine and evaluate the antiurolithiatic activity of Katurai (Sesbania grandiflora) against Calcium Oxalate injection induced in albino rats. In this study, evalutaion of Katurai extract has been made against ammonium oxalate rich diet and gentamicin injections induced kidney stone induced in albino rats. Extracts were orally administered to the test animals. The animals were divided into six groups each consisting of 6 Albino rats. Group 1 only received water and pellets, group 2 received 5% ammonium oxalate, gentamicin sulfate solution and Sambong, group 3 received 5% ammonium oxalate, gentamicin solution, group 4 to 5 received 5% ammonium oxalate, gentamicin solution and 50%, 75%, and 100% katurai extract, respectively. After 15 days of induction and treatment, parameters such as serum analysis, macroscopic and histopathological examination were studied. In serum analysis, creatinine, urea and uric acid levels were determined. Macroscopically, the color of the kidney was observed. Moreover, indicators for kidney tissue damage such presence of mottling, calcification, tubule dilation, necrosis were considered in histopathological examination. Results and Discussion. The serum urea, serum creatinine and serum uric acid values of the untreated albino rats were higher than given normal range, compared to the treated albino rats. Statistically, only 100% treatment group showed significant difference in all the serum parameters such as urea, creatinine, and uric acid compared to the negative control (group 3). Macroscopically, kidneys in the group 6 were in normal color of kidney when fixed with formalin solution. In histopathological examination, 100% treatment group exhibited the least kidney tissue damage. Conclusions. Results showed that in the terms of serum analysis, macroscopic and histopathological examination, Sesbania grandiflora leaves extract can prevent kidney stone formation in the test animals
Dissertation note: Thesis (unpublished)--Lorma Colleges, San Fernando City, La Union, 2018.
Tags from this library: No tags from this library for this title.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Collection Call number Status Notes Date due Barcode
Thesis Lorma Colleges Learning Commons - CHS Campus College Thesis PHA-TH 00026 B14 2018 (Browse shelf(Opens below)) Available For Library Use Only. PHA-TH00026

Thesis (unpublished)--Lorma Colleges, San Fernando City, La Union, 2018.

Includes bibliographical references.

Kidney stone disease remains a significant health problem in the adult population, with serious medical consequences, throughout a patient's lifetime. Thus, the aim of this study is to raise awareness regarding the medicinal use of plants other than edibility. It also aimed to determine and evaluate the antiurolithiatic activity of Katurai (Sesbania grandiflora) against Calcium Oxalate injection induced in albino rats.
In this study, evalutaion of Katurai extract has been made against ammonium oxalate rich diet and gentamicin injections induced kidney stone induced in albino rats. Extracts were orally administered to the test animals. The animals were divided into six groups each consisting of 6 Albino rats. Group 1 only received water and pellets, group 2 received 5% ammonium oxalate, gentamicin sulfate solution and Sambong, group 3 received 5% ammonium oxalate, gentamicin solution, group 4 to 5 received 5% ammonium oxalate, gentamicin solution and 50%, 75%, and 100% katurai extract, respectively. After 15 days of induction and treatment, parameters such as serum analysis, macroscopic and histopathological examination were studied. In serum analysis, creatinine, urea and uric acid levels were determined. Macroscopically, the color of the kidney was observed. Moreover, indicators for kidney tissue damage such presence of mottling, calcification, tubule dilation, necrosis were considered in histopathological examination.

Results and Discussion. The serum urea, serum creatinine and serum uric acid values of the untreated albino rats were higher than given normal range, compared to the treated albino rats. Statistically, only 100% treatment group showed significant difference in all the serum parameters such as urea, creatinine, and uric acid compared to the negative control (group 3). Macroscopically, kidneys in the group 6 were in normal color of kidney when fixed with formalin solution. In histopathological examination, 100% treatment group exhibited the least kidney tissue damage.

Conclusions. Results showed that in the terms of serum analysis, macroscopic and histopathological examination, Sesbania grandiflora leaves extract can prevent kidney stone formation in the test animals

There are no comments on this title.

to post a comment.