The antiemetic activity of fire tree leaves (Delonix regia, Fabaceae) in chick and conformance of the formulated tablet to USP standards / Michael Angelo D. Guerrero, Princess Wailey E. Azura, Dandy Mae A. Bustamante, Jenna N. Vicente; faculty researcher, Vanessa Samarah G. Liwan

By: Contributor(s): Publication details: 2018. : Description: Subject(s): DDC classification:
  • PHA-TH 00031 C17 2018
Contents:
Vomiting is an uncontrollable reflex that expels the contents of the stomach through the mouth. Nausea is a term that describes the unpleasant subjective sensation of the need to vomit that may or may not result to vomiting. The aim of the study is to determine the level of effectiveness of the Deloni regia leaves extracts as an antiemetic agent. The study aims to formulate an effective drug as an alternative for commercially available tablet that can be used as antiemetic. Delonix regia commonly known as the Fire tree which belongs to the family Fabaceae. The Delonix regia leaves were collected and thoroughly washed and air dried. The dried leaves were pulverized and macerated with 95% methanol with 1:1 ration. The extract of Delonix regia was subjected in phytochemical screening; where constituents such as alkaloids, flavonoids, saponins, and triterpenes were detected. An acute oral toxicity test was performed to determine the highest safe dose. Concentrations of 25%, 50%, 75%, and 100% was prepared which was used in the determination of antiemetic activity using chick emesis model. Prior to the experiment, the test animal, chicks with ages ranging from 4-15 days. After the evaluation of the plant extract, the most effective concentration was used in the formulation of tablet and was subjected to different tests to conform USP standards for tablets. Results and Discussions. Data and results were gathered from the experiment. The group of chicks treated with metoclopramide and was found to have a lower mean retch of the negative control group; thus metoclopramide reduced the retches. The 100% extract was comparable to the 25%, 50%, and 75%. The lower number retching, the more effective concentration. The 100% leaves extract have shown to be the most effective. However, metoclopramide still has shown to be the most effective. However, metoclopramide still has the highest antiemetic activity. Conclusion. The 100% Delonix regia extract preparation exhibited to be the highest among the extract as compared to the different extract concentration. The results shows that the 100% extract preparation has a significant effect in the reduction of retching and not comparable with the positive control. Therefore, it is effective as an antiemetic agent.
Dissertation note: Thesis(unpublished)--Lorma Colleges, San Fernando City, La Union, 2018.
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Thesis Lorma Colleges Learning Commons - CHS Campus College Thesis PHA-TH 00031 C17 2018 (Browse shelf(Opens below)) Available For Library Use Only. PHA-TH00031

Thesis(unpublished)--Lorma Colleges, San Fernando City, La Union, 2018.

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Vomiting is an uncontrollable reflex that expels the contents of the stomach through the mouth. Nausea is a term that describes the unpleasant subjective sensation of the need to vomit that may or may not result to vomiting. The aim of the study is to determine the level of effectiveness of the Deloni regia leaves extracts as an antiemetic agent. The study aims to formulate an effective drug as an alternative for commercially available tablet that can be used as antiemetic.
Delonix regia commonly known as the Fire tree which belongs to the family Fabaceae. The Delonix regia leaves were collected and thoroughly washed and air dried. The dried leaves were pulverized and macerated with 95% methanol with 1:1 ration. The extract of Delonix regia was subjected in phytochemical screening; where constituents such as alkaloids, flavonoids, saponins, and triterpenes were detected. An acute oral toxicity test was performed to determine the highest safe dose. Concentrations of 25%, 50%, 75%, and 100% was prepared which was used in the determination of antiemetic activity using chick emesis model. Prior to the experiment, the test animal, chicks with ages ranging from 4-15 days. After the evaluation of the plant extract, the most effective concentration was used in the formulation of tablet and was subjected to different tests to conform USP standards for tablets.

Results and Discussions. Data and results were gathered from the experiment. The group of chicks treated with metoclopramide and was found to have a lower mean retch of the negative control group; thus metoclopramide reduced the retches. The 100% extract was comparable to the 25%, 50%, and 75%. The lower number retching, the more effective concentration. The 100% leaves extract have shown to be the most effective. However, metoclopramide still has shown to be the most effective. However, metoclopramide still has the highest antiemetic activity.

Conclusion. The 100% Delonix regia extract preparation exhibited to be the highest among the extract as compared to the different extract concentration. The results shows that the 100% extract preparation has a significant effect in the reduction of retching and not comparable with the positive control. Therefore, it is effective as an antiemetic agent.

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